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It Works SLMR Review – Benefits, Ingredients, Research and Results

About It Works SLMR

It Works SLMR, is a weight loss product designed to reduce hunger and improve satiety.  By consuming less calories the body can more easily lose weight.  SLMR is a vitamin capsule to be taken daily.  

It Works SLMR contain Dyglomera®, a powerful ingredient that has been the subject of extensive study, and clinically proven to stimulate significant weight loss in as little as eight weeks  (0)  Dyglomera® contains unique polyphenol bioactives that can assist to accomplish healthier weight management and improved metabolic balance (0)

Some of the key ingredients in SLMR include:

  • Dyglomera® (clinically studied ingredient) – can help to achieve weight loss and reduction in body fat in eight weeks!

Pros of It Works SLMR :

  • Regulate your appetite by resetting your body’s appestat response†
  • Features Dyglomera® clinically studied to help achieve significant weight loss†
  • Increases appetite control with continued use†
  • Stimulant-free
  • Vegan
  • Promotes healthy weight management†
  • Dyglomera® was clinically tested to promote weight loss activity†
  • Helps promote weight loss†
**Appestat response the part of the hypothalamus of the brain which is believed to influence a person’s appetite for eating.
†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Serving Size: 1 Capsule. Servings Per Container: 30

Amount Per Serving: IT WORKS! Proprietary Appetite Reset Blend 410 mg*: Dyglomera® Dichrostachys glomerata fruit extract (standardized to 10% polyphenols), Bitter melon fruit extract, Gymnema leaf extract, Irvingia gabonensis IGOB 131® seed extract, Lactobacillus gasseri.

*Daily value (DV) not established.

Other Ingredients

Microcrystalline cellulose, hypromellose (veggie capsule), magnesium stearate, and silica.

Active Ingredients in It Works SLMR


Dyglomera® is a patented natural extract of African spice fruit (Dichrostachys glomerate) that clinical research showed to improve healthy weight loss and cardiovascular health by restoring metabolic balance.

How Does Dyglomera Work?

Dyglomera promotes metabolic wellness as well as a healthy body weight and composition by utilizing complementary mechanisms that govern satiety and appetite (2).

  • Improves insulin sensitivity, allowing the body to metabolize sugar into energy rather than storing it as fat.
  • Fights free radicals and inhibits LDL oxidation to reduce oxidative stress and promote cellular health.

Bitter melon fruit extract

Bitter melon contains antioxidant-rich components such as alpha-carotene, beta-carotene, lutein, and zeaxanthin.  According to some studies, bitter melon may help the body manage healthy blood sugar levels. 

Gymnema leaf extract : 

Gymnema leaf extract is said to reduce sugar cravings while also slowing down the absorption of sugar and fat in the body. May assist with weight management and managing cholesterol (1).

It Works SLMR Research

Dyglomera Research


Dyglomera has been shown to be beneficial in weight loss (2). This plant has been demonstrated to have several biological features and to have no harmful or negative side effects in animals. The purpose of this human clinical trial was to determine if Dyglomera could lower body fat percentage after 8 weeks.


The clinical trial was a 8-week double-blind placebo-controlled randomized experiment, with a total of 120 participants.  Each participant received either a single dose of Dyglomera 400 mg once a day or a placebo.  Participants assigned to either the test or placebo groups were chosen at random. At the start of each of the five study visits, evaluations were performed to measure weight loss and metabolism.


Human clinical research demonstrated that Dyglomera successfully reduced body weight, body fat, waist and hip circumference, as well as improving triglycerides, cholesterol, adiponectin, C-reactive protein and blood pressure levels (2). 

At baseline and after four to eight weeks of supplementation, sixteen parameters, including biochemistry, body weight, and body composition, were measured. The Dyglomera group demonstrated statistically significant improvements in all study measurements including :

  • Lost an average of 24.5 lbs.*

  • Reduced body fat on average of 10.7 lbs.*

  • Reduced waist and hip circumferences 10.2% and 7.1%, respectively.*

The changes in body weight and composition were accompanied by improvements in major biochemical indicators (blood triglycerides, insulin, adiponectin, C-reactive protein, and cholesterol).  Many biological reactions that govern metabolic health and weight management can be restored to normal levels by Dyglomera, according to these findings and other research (3).

Bitter melon fruit extract Research

May Reduce Blood Sugar

In a three-month study of 24 people with diabetes, taking 2,000 mg of bitter melon extract daily reduced blood sugar and hemoglobin. (4).   Another study of 40 individuals with diabetes discovered that taking 2,000 mg of bitter melon daily for four weeks resulted in a modest decrease in blood sugar levels(5).  Furthermore, the supplement substantially reduced fructosamine levels, another bio-marker of long-term blood sugar control (5).
Bitter melon extract is believed to improve the way sugar is used in the body as well as increasing insulin secretion, the hormone responsible for controlling blood sugar levels. (6).

Can Decrease Cholesterol Levels

In one clinical trial bitter melon extract significantly reduced levels of total cholesterol as well as “bad” LDL cholesterol, and triglycerides (81).  Another study found that giving rats a bitter melon extract reduced cholesterol levels considerably more than the placebo. The largest reduction  in cholesterol levels were seen at higher doses of bitter melon. (8).

May Assist with Weight Loss

According to some studies, bitter melon extract improved fat burning and weight reduction.  One clinical trial discovered that taking a capsule containing 4.8g  of bitter melon extract every day resulted in significant reductions in belly fat (9).  After seven weeks, participants dropped an average of 0.5 inch (1.3 cm) from their waist circumference (9).

Similarly, in a trial of rats fed a high-fat diet, bitter melon extract was found to reduce body weight of the rats, when compared to a placebo. (10).

**Disclaimer :  

*This website is intended to provide scientific and educational information only. These statements have not been evaluated by the U.S. Food and Drug Administration nor any other regulatory agency in any country. Manufacturers should consult with their legal counsel to confirm the appropriateness of claim language in their respective region.


Work Cited :
Kim, H L.  “Anti-Obesity Effect of Dyglomera® Is Associated with Activation of the AMPK Signaling Pathway in 3T3-L1 Adipocytes and Mice with High-Fat Diet-Induced Obesity.”